McCloud makes a few points that I take into my own work. First is that what is on the “page” is not the thing, it is at best 2 existences away from the thing. It is a symbol that is either digitally or physically being given to the user. This means that there is a lot of leeway in what that represented symbol can mean to the user. showing someone a picture of an Orange can elicit different understandings than just showing them a physical Orange. You wont get all of the sensory input, especially depending on the limitations of your medium. However you can have more control in their perception of the subject. You can control the environment, the tone, and potential extra knowledge about the subject.
Another point he talks about is how a user sequentially experiences your work. Different cultures read in opposite directions, and when you give your work to an audience you have to know how they are going to perceive it. I usually try to give my work multiple angles to perceive it from, if a visual work, create different meaning depending on the visual hierarchy the user uses. I find it fun to create interactive experiences and imagine that some users will find fun puzzling out different meanings or stories from them.
The final point I take away is the importance of what transitions you choose to use in your work. Each one brings different experiences, some can slow the reading down to create tension or give more information by overviewing an environment. It was also interesting seeing the difference the direct constraints of a medium and the cultural expectations created in the use of transitions. Where episodic comics that sell chapters at a time used more time saving transitions as opposed to manga which are usually sold a book at time taking more time and giving more aspects of a scene.
*Bonus*
The touch on object permanence(closure) was really fun to read about in a literary sense. Even in someplace like videogame design this can apply since unperceived assets are usually not loaded but you still need to have a user think the whole world is there.